Complement C2; Human

Code: 204882-50UG D2-231

General description

Native, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activa...


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€529.00 EACH
€650.67 inc. VAT

General description

Native, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Attwood, J.T., et al. 2001. Acta Paediatr.90, 99.

Packaging

50 µg in Plastic ampoule

Please refer to vial label for lot-specific concentration.

Physical form

In PBS, pH 6.0.

Preparation Note

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Warning

Toxicity: Standard Handling (A)

assay≥90% (SDS-PAGE)
formliquid
impuritiesC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin, trace
manufacturer/tradenameCalbiochem®
Quality Level100
shipped inwet ice
specific activity≥4×105 C2H50 units/mg (>=70% of the C2 activity in normal human serum on a mg/mg basis)
storage conditionavoid repeated freeze/thaw cycles, OK to freeze
storage temp.−70°C
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